Showing posts with label diabetes. Show all posts
Showing posts with label diabetes. Show all posts

Monday, May 05, 2008

Ayurveda Herbal Remedy for Regulating Blood Sugar

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Sunday, December 30, 2007

Childhood Diabetes Boosts Risk for Kidney Problems

(HealthDay News) -- As more and more American children are diagnosed with type 2 diabetes, another serious problem is threatening their health.

Children and teens diagnosed with type 2 diabetes are five times more likely to develop kidney disease later in life than those who develop diabetes as adults, a recent study found.

The findings underscore the importance of preventing -- or at least delaying -- the onset of type 2 diabetes, doctors say.

"Since the development of diabetic kidney disease is strongly dependent on the duration of diabetes, developing diabetes in youth leads to a high risk of kidney disease in early- to mid-adulthood," said study author Dr. Robert G. Nelson, a staff clinician with the U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

"For example," he said, "a 15-year-old person with 10 years of type 2 diabetes has the same risk of kidney disease as a 55-year-old with 10 years of type 2 diabetes."

Diabetes is becoming increasingly prevalent among children and teens, largely due to the obesity epidemic. The U.S. Centers for Disease Control and Prevention estimates that among new cases of childhood diabetes, up to 43 percent are type 2 disease.

While type 2 diabetes can affect children of any race or ethnic group, it's more common among non-white individuals, the CDC reports. The Pima Indians of Arizona currently have the highest recorded rates of diabetes in the world, at 50.9 per 1,000 individuals, according to the CDC.

Diabetes is the most common cause of kidney failure. Initially, small amounts of albumin, a blood protein, begin to leak into the urine. As the amount of albumin in the urine increases, the filtering function of the kidneys begins to decline. It may take 15 to 25 years for kidney failure to occur. Native Americans, blacks and Hispanics have higher rates of kidney failure from diabetes, the NIDDK said.

Nelson and his colleagues examined the relationship between a person's age at the onset of diabetes and the likelihood that they would have "end-stage renal disease," or kidney failure.

The study, published recently in the Journal of the American Medical Association, was based on data collected over four decades from more than 1,800 members of the Pima and closely related Papago Indian tribes. The researchers compared people who were diagnosed with type 2 diabetes before the age of 20 with those who developed the disease between ages 25 and 55.

Breaking down the numbers by age range, people who developed type 2 diabetes before age 20 were eight times more likely to experience kidney failure between 25 and 34 than those diagnosed after 20. And the younger diabetics were four times more likely to have kidney failure between the ages of 45 and 54 than those diagnosed at an older age.

Dr. Pascale H. Lane is a diabetic neuropathy specialist and associate chairwoman for research at the University of Nebraska Medical Center's Department of Pediatrics. She believes that patients and parents of children with diabetes need to be aware of the potential complications of type 2 diabetes and ways to minimize the risk.

"Nephropathy [kidney failure] may be prevented by strict control of blood sugar levels and by not smoking," Lane said. "Diagnosing and treating high blood pressure early and aggressively may also prevent or slow the development of this kidney disease."

Efforts also need to focus on preventing type 2 diabetes in children through lifestyle changes that emphasize weight loss and increased exercise, Nelson added.

"The explosion of obesity in children and adolescents is a cause for great concern and must be reversed," he said. "Calorie-dense fast foods must be replaced by healthy alternatives provided in reasonable portions, and hours of TV watching must be replaced by activities that require exercise."

More information
Visit the National Kidney Foundation for more on diabetes and kidney disease.


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Thursday, December 06, 2007

Overweight Kids Often Become Obese, Unhealthy Adults

(HealthDay News) -- Overweight children and adolescents are more likely to be overweight or obese adults and more likely to suffer early heart disease and death, two new studies conclude.

The first, out of Denmark, found that large children, especially boys, are at an increased risk of coronary heart disease as adults.

The second, based on a computer model, found that overweight adolescents are more likely to end up with heart disease and even dying in early adulthood.

"Teenage and childhood weight does matter," said Dr. Thomas R. Kimball, a pediatric cardiologist with Cincinnati Children's Hospital Medical Center. "This is not a problem of middle-aged adults. This is a problem that we have to face as a society in our children."

"When you see a shift at this level across the entire population, it really suggests that this is a major public health problem and requires intervention that really needs to be reinforced at every level of policy makers, every level of institutions," said Dr. Kirsten Bibbins-Domingo, lead author of the computer modeling study.

"This is more than just a problem of overweight adolescents and their parents. It's a problem that requires really a concerted effort at federal, state, local policy levels to reinforce the availability of healthy foods for kids and the availability of physical activity. We really want to prevent obesity before it starts," said Bibbins-Domingo, who is assistant professor of medicine, epidemiology and biostatistics and the Robert Wood Johnson Harold Amos Medical Faculty Scholar at the University of California, San Francisco.

Both studies are published in the Dec. 6 issue of the New England Journal of Medicine.

The overweight and obesity crisis is reaching epidemic proportions around the world. In the United States, federal statistics estimate that 9 million adolescents (17 percent of the population) are overweight and 80 percent of overweight adolescents grow up to be obese adults. Childhood obesity rates have tripled since 1970.

Worldwide, children are becoming heavier at younger and younger ages. In the United States, 19 percent of kids between the ages of 6 and 11 are overweight.

Being overweight or obese puts you at risk of heart disease, diabetes, cancer and other ills.
The first study looked at a group of almost 277,000 Danish children -- all schoolchildren in Copenhagen -- from 1930 to 1976.

Out of that initial group, more than 10,200 men and 4,300 women were identified whose childhood body-mass index (BMI) data were available and who had received a diagnosis of coronary heart disease (CHD) or died of CHD as adults.

Boys with a higher BMI at 7 to 13 years of age and girls with a higher BMI from 10 to 13 years of age had a higher risk of a heart disease event in adulthood, the researchers found.

The authors used as an example a 13-year-old boy who weighs 11.2 kilograms (24.6 pounds) more than average boy his age. He now has a 33 percent increase in the probability of having a coronary event before he turns 60, the Danish team said.

"It's scary," Kimball said. "We knew that if you're an overweight kid, you're at a higher risk to be an overweight adult. This study goes a step further. It's proving that you have an increased risk of cardiovascular events as early as 25 years of age."

The second study projected the number of overweight adults based on the number of overweight adolescents in 2000.

Using a computer model, it predicted that up to 37 percent of men and 44 percent of women will be obese when these people -- now teenagers -- turn 35 in 2020.

This could result in up to 5,000 additional deaths from heart disease and 45,000 heart attacks, cardiac arrests and related events by 2035 among this group of young adults. It would raise the death toll from obesity-related coronary heart disease by 19 percent.

"To some extent, we're not surprised. We know it's not good to be overweight at any age but we were really struck by the magnitude of this increase," said Bibbins-Domingo. "We're modeling a young adult population 35 to 50 years. These are people who should be working and raising families, not worrying about heart disease, and we're suggesting more will be hospitalized for heart attacks, will need chronic medication to manage high blood pressure and high cholesterol, and many more will actually die before the age of 50."

More information
To learn more about the government's We Can! Program regarding childhood obesity, visit the U.S. National Heart, Lung, and Blood Institute.

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Saturday, December 01, 2007

Diets May Raise Cancer Risk for Poor, Urban Women

(HealthDay News) -- It can be difficult for women in America's inner cities to eat in ways that may help prevent cancer.

That's the conclusion of a Johns Hopkins University study that looked at the dietary habits of 156 black women living in 11 public housing communities in Washington, D.C.

The researchers found that about 61 percent of the women failed to meet more than one of the five dietary goals suggested to reduce the risk of developing cancer: adequate consumption of fruits and vegetables; low percentage of fat intake; moderate caloric intake; no alcohol consumption; and adherence to the U.S. Department of Agriculture's Healthy Eating Index, a measure of overall quality of diet.

Less than 1 percent met all five dietary goals, and only 15 percent reported eating at least five servings of fruits or vegetables a day.

"Many women drank soda, and ate convenience and prepared foods, even when they sat down with their families for a meal. Younger adults, especially, seem to lack the skills to build a well-balanced diet -- skills that our survey shows that older generations of women still possess," Ann C. Klassen, an associate professor in the department of health, behavior and society at Hopkins' Bloomberg School of Public Health, said in a prepared statement.

The study was scheduled to be presented Wednesday at the American Association for Cancer Research conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, in Atlanta.

"African-American women, in general, face a worse cancer incidence and mortality rate than most other ethnic groups, and poor African-American women are at an even greater disadvantage. Improving diet is one effective way to help women lower their risk for developing cancer," Klassen said.

More information
The U.S. National Cancer Institute has more about cancer prevention.

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Wednesday, November 28, 2007

Health Tip: Build Healthy Bones

(HealthDay News) - Osteoporosis doesn't have to be an inevitable part of aging -- if you begin practicing healthy habits when you're young.

Here are some facts about osteoporosis, and suggestions to help prevent brittle bones, courtesy of the American Academy of Orthopaedic Surgeons:
  • Women who are or have been pregnant, who are breast-feeding, or who have had a hysterectomy are more likely to lose bone mass, putting them at higher risk of osteoporosis.
  • Women who are menopausal or postmenopausal produce less estrogen than before, which weakens bones.
  • Ideally, weight-bearing exercises should begin during the teen years, when the bones grow rapidly.
  • It's never too late to start protecting your bones, which may continue to grow throughout your 20s, and even into your early 30s.
  • Avoid smoking and excess alcohol, which weaken bones.

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Saturday, November 24, 2007

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Wednesday, November 21, 2007

Health Tip: Before a Wart is Removed

(HealthDay News) - Before your doctor removes a wart, often by a freezing process called cryosurgery, there are things you can do to prepare for the procedure.

The American Academy of Family Physicians offers these suggestions:

  • For two weeks, thoroughly clean the wart with soap and water each night. Once it is dry, apply a salicylic acid gel to the wart.
  • Once the gel has been applied, cover the wart with a salicylic acid pad. Be sure the pad is large enough to cover the wart completely.
  • Keep the pad on the wart for 24 hours. Repeat this process once daily until the removal procedure.
  • If the wart becomes red and sore, discontinue using the gel and see your doctor.

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Sunday, November 18, 2007

Health Tip: Sledding Safely

(HealthDay News) - Sledding may be a long-anticipated part of a child's winter fun, but it also can lead to injuries.

Follow these safety tips to prevent accidents, courtesy of the National Safety Council:
  • Before use of any sled or toboggan, parents should carefully inspect them for any broken parts or sharp pieces.
  • Children who are 8 years old or younger shouldn't sled unsupervised.
  • Dress warmly and in layers, including a hat and gloves.
  • Sled only in wide-open areas that are far from lakes, roads and traffic.
  • Don't sled down extremely steep hills.
  • Don't sled in areas with trees, rocks, shrubs and other potential obstacles.
  • Don't sled down a hill head-first -- always feet-first.

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Wednesday, November 14, 2007

Health Tip: Preventing Dry Eyes

(HealthDay News) - Dry eyes can be triggered by aging, eyestrain, exposure to sun, wind or smoke, or injury.

The U.S. National Library of Medicine offers these suggestions to help soothe dry eyes:
Use artificial tears, or other moisturizing eye drops or ointments.

Avoid smoking, and exposure to secondhand smoke.

Avoid direct exposure to wind or air conditioning.
Use a humidifier in your home, particularly during the dry winter months.

Rest your eyes, and blink often.

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Saturday, November 10, 2007

Health Tip: When a Stomachache Requires Medical Attention

(HealthDay News) - While stomachache or abdominal pain are quite common and often harmless, these conditions sometimes can signal a more serious problem.

The U.S. National Library of Medicine says the following symptoms require a trip to the emergency room:
  • Very sharp, severe and sudden pain.
  • Fever along with your stomach or abdominal pain.
  • Vomiting blood, or having bloody diarrhea.
  • Soreness or tenderness in the abdomen.
  • An abdomen that is hard and rigid.
  • Inability to have a bowel movement, particularly if you are also vomiting.
  • Pain in the chest, neck or shoulder.
  • Dizziness or lightheadedness.

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Friday, October 19, 2007

Chronic Reflux Often Leads to Sleepless Nights

(HealthDay News) -- Along with typical symptoms such as acid reflux, the less typical symptoms of gastroesophageal reflux disease (GERD) -- such as coughing, choking, wheezing, choking, snoring, sore throat, and chest pain -- can cause people significant sleep problems, according to a new U.S. survey.

The poll of 701 GERD patients found that sleep impairment was much more common among those with GERD (41.9 percent) than among people without GERD (19.4 percent), and that about half of people with nighttime GERD reported sleeping poorly often or most of the time, compared to 36.7 percent of those with daytime GERD.

Among GERD patients, 74 percent reported at least one nighttime atypical symptom. For almost every atypical symptom in the study, more than 20 percent of GERD patients reported that the symptom occurred frequently -- more than two nights a week.

The survey also found that GERD patients with atypical symptoms were more likely to suffer sleep problems than GERD patients with typical symptoms such as heartburn and acid regurgitation.

The percentage of GERD patients who reported sleeping problems was much higher for those reporting eight out of nine of the atypical symptoms included in the survey than for these without atypical symptoms.

The findings were presented this week at the annual scientific meeting of the American College of Gastroenterology, in Philadelphia.

More information
The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about GERD.

Wednesday, October 03, 2007

Panic Attacks May Hike Heart Disease Risk in Women

(HealthDay News) -- Postmenopausal women who've had at least one panic attack may be at greater risk for heart disease, stroke and even death, new research suggests.

The study found that older women with a history of panic attacks were four times more likely to have heart disease than women who hadn't had a panic attack.

"Women who reported at least one panic attack were at higher risk of having cardiovascular illness and death after an average of five years of follow-up. Even after controlling for other risk factors, a panic attack remained an independent risk factor on its own," said study author Dr. Jordan Smoller, an associate professor of psychiatry at Harvard Medical School.

Symptoms of a panic attack include a sudden feeling of fear, anxiety or extreme discomfort that's out of proportion to your current situation. Panic attacks may also be accompanied by a rapid or irregular heartbeat, sweating, hot flashes, chills, chest pain, difficulty breathing, shaking, dizziness and a feeling that you might die. About one in 10 postmenopausal women has had at least one panic attack, according to the study.

The research, published in the October issue of the Archives of General Psychiatry, included 3,369 postmenopausal women between the ages of 51 and 83. All of the women completed questionnaires about the occurrence of panic attacks in the previous six months. A full-blown panic attack was one in which sudden fear was accompanied by at least four other panic attack symptoms. A limited panic attack was one in which fear was accompanied by one to three additional symptoms.

After an average 5.3 years of follow-up, the researchers collected information on heart disease, stroke and death from any cause. The researchers also adjusted the data to account for other known cardiovascular disease risk factors, such as weight, alcohol use, hormone use, high cholesterol, high blood pressure, age, diabetes and smoking history.

After adjusting for all those factors, the researchers found that full-blown panic attacks were associated with a fourfold higher risk of heart disease, nearly twice the risk of stroke, and a 75 percent increase in risk of death from any cause, compared to women who'd experienced no panic attacks. Women who'd had limited panic attacks fared somewhat better. The adjusted risk of heart disease was 65 percent higher, stroke risk was more than doubled, and all-cause mortality was increased by 34 percent.

"Negative emotional states and psychiatric symptoms can be related to adverse medical outcomes," said Smoller, who's also assistant vice chairman of the department of psychiatry at Massachusetts General Hospital.

"Panic attacks may be having a direct effect on cardiovascular health -- anxiety, panic and other negative emotional states have been related to changes in heart rhythm and changes in cardiac blood flow in previous studies. It may be that stress hormones and other components of the 'fight-or-flight' reactions that accompany panic directly impact the cardiovascular system," he said.

"Or," he added, "it could be that panic attacks are simply a marker for increased risk that is due to something other than the panic attacks themselves. It might be that the women who were experiencing panic might have been experiencing some other unrecognized cardiovascular problem."

Dr. Stephen Siegel, a cardiologist at New York University Medical Center, said the study definitely raises some interesting questions, but more research needs to be done to establish a definite link between panic attacks and cardiovascular health.

In the meantime, Siegel recommended that all women do whatever they can to reduce their cardiovascular disease risk factors. "Control all the known risk factors out there -- hypertension, cigarette smoking, diabetes, elevated cholesterol. We can make changes in these factors and we know they make a difference," he said.

Exercise is another great -- and proven -- option, Siegel said. Not only does it improve your heart health by lowering blood sugar, blood pressure and cholesterol, but exercise can also help ease anxiety and depression, providing both a physical and psychological benefit.

More information
To learn more about panic attacks and panic disorder, visit the American Psychological Association.

Friday, September 28, 2007

Fried Food Compounds May Harm Heart

(HealthDay News) -- Foods high in compounds called advanced glycation end products (AGEs) -- such as hamburgers, french fries and other fatty foods cooked at high temperatures -- cause a short-lived but significant dysfunction in blood vessel dilation that can lead to heart disease, a new study suggests.

"Although the effect was temporary, it suggests that AGEs could, over time, pose a significant risk to the vascular integrity of both diabetic and healthy persons," lead researcher Dr Jaime Uribarri, of the Mount Sinai School of Medicine, said in a prepared statement.

His team published its findings in the journal Diabetes Care.

High levels of AGEs are formed when foods rich in protein and fat are cooked at high and dry heat, including broiling, grilling, frying or roasting. Foods that are steam-cooked or stewed tend to have lower AGE concentrations, the researchers explained.

Previous research has found AGEs to be associated with a number of diabetes-associated chronic conditions, such as heart disease. This study found that consuming an AGE-rich beverage caused significant endothelial dysfunction in both people with diabetes and in people without diabetes.

Endothelial dysfunction is an early indicator of hardening of the arteries (atherosclerosis), which leads to heart disease, the study authors noted.

More information
The MedlinePlus Medical Encyclopedia has more about heart disease and diet.

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Monday, September 24, 2007

Cataract Surgery: A Bargain, Despite the Price

(HealthDay News) -- Everyone, if they live long enough, will suffer from a cataract that clouds the vision in one or both eyes.

Because of that, doctors expect spending on cataract surgery to surge in the coming decades as the population ages, part of an overall increase in vision costs among older Americans.
However, it's money well spent, experts say.

Cataract surgery is one of the most cost-effective surgical procedures to address vision problems in seniors, said David B. Rein, a researcher with RTI International in Research Triangle Park, N.C., who authored a recent study of the economic costs of vision disorders.

"It gives a great amount of benefit in terms of years of unimpaired vision, compared with dollars spent," Rein said.

In fact, it's one of the only therapies that actually cures the condition, rather than simply holding the line against future deterioration.

"You're removing a lens that is clouded, a dirty lens, and you're replacing it with a lens that's clear," Rein said.

A cataract is a clouding of the lens in the eye, which affects a person's ability to see clearly. Most cataracts are related to aging. By age 80, more than half of all Americans either have a cataract or have had cataract surgery, according to the U.S. National Eye Institute.

Major vision problems cost the U.S. economy about $35.4 billion a year, including $16.2 billion in direct medical costs. And because cataracts are frequent and inevitable, they make up the biggest chunk of those direct costs -- about $6.8 billion, according to Rein's research.

The primary way to treat cataracts is to remove the eye's lens and replace it with an artificial one.

These surgeries have been around for decades, and doctors have become remarkably adept at performing them, said Dr. Marco Zarbin, professor and chairman of the Institute of Ophthalmology and Visual Science in New Jersey.

"During the past quarter century, there have been remarkable advances," Zarbin said. "Ninety-five percent of patients report impressive improvement in their vision."

Most cataract surgery removes the lens through phacoemulsification, in which a probe inserted through a small incision in the side of the cornea breaks the lens into tiny pieces using ultrasonic waves. The surgeon then removes the pieces using suction.

This technique has gone through countless refinements, Zarbin said, and is far evolved from traditional cataract surgery. In that procedure, the lens was simply cut away.

"Back in the 1960s, people were kept in the hospital for two weeks following cataract surgery," he said. "Their heads were held in place with sandbags. Now, people have the surgery with topical anesthesia and go home the same day. It's just what you'd hope for in medicine. It's really true progress."

The replacement lenses are also improving.

In early days, patients were fitted with a lens that only provided one range of focus. Near could be in focus, or far, but not both.

But improvements in intraocular lenses are producing results that are coming closer and closer to mimicking the human eye, allowing people to change their focus from near to far.

"There's a real push to develop intraocular lenses that give people focus at distance and near," Zarbin said. "There's a real interest in improving those capabilities. I'm very sure that one day that's the lens that everyone will get, an accommodative lens."

These improvements mean that, even though more money is being spent on cataract surgery, the American people are getting a bigger bang for their buck, Rein said.

"Compare the cost for cataract extraction surgery to the treatments that address age-related macular degeneration or diabetic retinopathy," he said. "The costs are much lower, and the results are much better."

Patients can actually expect improved vision, rather than vision that simply won't get worse.
"When you're treating glaucoma or diabetic retinopathy, you're trying to prevent further visual impairment from occurring," Rein said. "With cataracts, you can restore their vision to what it was before."

Cataract surgery also helps keep older people entertained and more engaged, Zarbin said. "I think when you're older and have a less active lifestyle, things like reading and watching television gain a greater importance," he said.

"You also have to consider the cost of taking care of those patients if you didn't have the therapy to treat them. We are way ahead as a society by paying for those treatments, because they cost less than caring for all these debilitated and blind people," he added.

More information
To learn more about cataracts, visit the U.S. National Eye Institute.

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Friday, September 21, 2007

Childhood Obesity Epidemic a Long-Term Challenge

(HealthDay News) -- In the 1980s and '90s, Americans tried to control their weight by watching their cholesterol by cutting dietary fat and substituting carbohydrates. They paid little mind to total calories and physical activity. And guess what happened to their waistlines -- and their children's?

"It was just an end run around the issue of health maintenance," said Dr. Henry C. McGill Jr., senior scientist emeritus at the Southwest Foundation for Biomedical Research in San Antonio, Texas. "And, of course, it crept over into kids, especially kids subjected to all of the advertising and offerings of high-density caloric food -- opportunities to avoid physical activity, attractions to television viewing and net surfing."

Today, more than one in three children and adolescents in the United States -- some 25 million kids -- are overweight or obese, according to the Robert Wood Johnson Foundation, which recently announced an unprecedented effort to reverse the childhood obesity epidemic by 2015.
The Princeton, N.J.-based philanthropy said it plans to spend at least $500 million over the next five years on public health efforts focusing on kids and families in underserved communities.

It's the foundation's largest commitment ever. While the foundation has spent roughly as much in the area of tobacco over the years, "we never made the scale of that commitment up-front and public like we have with this," said Dr. James S. Marks, senior vice president and director of the foundation's health group.

"If we don't deal with children," he added, "this could be the first generation that will live sicker and die younger than its parents."

Scientists, physicians and public health advocates know that efforts to prevent obesity must start in childhood, because the problem leads to increased risk of coronary heart disease and other health hazards in adulthood. In fact, there's substantial evidence that obesity and related diseases, including diabetes and hypertension, can begin to exact damage during the teenage years.

In one landmark study, a group of researchers from across the United States analyzed post-mortem blood samples and evaluated atherosclerosis in coronary artery and aorta specimens from roughly 3,000 15- to 34-year-old men and women who died from causes such as accidents, homicide or suicide. One of the surprising results of the study, according to McGill, was that an elevated blood sugar -- as measured by levels of "glycohemoglobin" -- was associated in the late 20s and early 30s with about an 8-fold increase in advanced lesions in the coronary arteries. "It was a whopper of an effect," he said.

In another study, published in the Journal of the American Medical Association, researchers documented a significant upward shift over the past 16 years in blood pressure levels of children and teens aged 8 to 18. Lead author Paul Muntner, an epidemiologist at Tulane University School of Medicine, and colleagues said the increase in blood pressure levels is partially due to the increased prevalence of overweight in the United States.

And British researchers recently reported that children who are overweight at age 11 continue to have weight problems through their teenage years. Rates of overweight and obesity were highest among girls and children from lower socioeconomic backgrounds. The authors said the study highlights the need to target efforts to prevent obesity in the early years.

But even as more money and manpower are devoted to obesity prevention, McGill said it may take many years to erase the epidemic. And, he added, it will take action on many different fronts, from educating children and physicians to improving the health-care financing system to include more preventive medicine.

"It was 1964 when the first U.S. Surgeon General's report came out, and just now, there's talk about the tide turning on cigarette smoking," he observed. "Obesity's perhaps going to take that long to get the tide turned."

More information
For more on childhood obesity, visit the U.S. Centers for Disease Control and Prevention.

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Tuesday, September 18, 2007

Gene May Influence Breast Cancer-Estrogen Link

(HealthDay News) -- U.S. researchers say they've found a gene that plays a crucial role in the ability of breast cancer cells to respond to estrogen.

The finding that transcription factor AP2C (TFAP2C) controls multiple pathways of estrogen signaling may lead to improved therapies for hormone-responsive breast cancer and may help explain differences in the effectiveness of current treatments, said a team from the University of Iowa.

The study was published in the Sept. 15 issue of the journal Cancer Research.

"Estrogen binds to estrogen receptors and triggers a cascade of events including gene regulation," study leader Dr. Ronald Weigel, professor and head of surgery at the university's college of medicine, said in a prepared statement.

"We found that elimination of TFAP2C from the cell causes all of those cascades that we associate with estrogen to go away," he said. "The treated cancer cells were not able to respond to estrogen by any normal pathway."

Silencing TFAP2C inhibited tumor growth in mice. It also halted expression of another estrogen receptor called GPR30, found at the cancer cell membrane.

"Targeting this gene may be a better way to develop drugs to treat hormone-responsive breast cancers, because it targets multiple different pathways," Weigel said.

More information
The American Cancer Society has more about breast cancer.

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Saturday, September 15, 2007

Tomato Diet Can't Guarantee Prostate Health: Study

(HealthDay News) -- Men who've been adding vitamin E or the tomato nutrient lycopene to their diets to cut their risk of prostate cancer may need to think again.

According to a new study, neither carotenoids (such as lycopene), retinol, nor tocopherols (forms of vitamin E) appear to reduce the odds of prostate malignancy -- findings that are in line with two other recent publications.

"Our overall findings are null," said lead researcher Timothy Key, deputy director of the Cancer Research UK Epidemiology Unit at the University of Oxford, U.K.

"This large study does not support the hypothesis that consuming large amounts of these nutrients will reduce prostate cancer," he added. "That is disappointing, but that is the overall message."

The findings are published in the September issue of the American Journal of Clinical Nutrition.

His team examined the effect of the blood levels of 10 micronutrients on the risk of developing prostate cancer for almost 2,000 males from eight European countries.

The research, which the authors call "the largest prospective study to date of plasma carotenoids, retinol, tocopherols, and prostate cancer risk," was part of the EPIC (European Prospective Investigation into Cancer and Nutrition) study, which includes more than half a million men and women.

The authors did find evidence to suggest that, once a cancer forms, high levels of lycopene (or of carotenoids in general, including lycopene) may reduce by about 60 percent the risk of the tumor progressing to an advanced-stage prostate cancer. Carotenoids appeared to have no effect on the rate of localized, earlier-stage disease, however.

According to Dr. Peter Scardino, head of the Prostate Cancer Program at Memorial Sloan-Kettering Cancer Center in New York City, prostate cancer is the most common cancer in men in the developed world. A Western male, he said, has about a 42 percent risk of developing cancerous cells in his prostate over his lifetime, a 16 percent risk of being diagnosed with the disease, and about a three percent risk of dying as a result. In other words, nearly one-quarter of Western males have a subclinical form of prostate cancer, which will never progress to more advanced disease.

Stopping progression is crucial. According to Scardino, for those whose disease does progress, the risk of death is much higher -- nearly 50 percent.

"I think it's an important study," Scardino said. That lycopene and bulk carotenoids reduced the risk of progressing to advanced disease without impacting the risk of developing prostate cancer overall, he said, "suggests maybe these micronutrients are not as important in [stopping] carcinogenesis as they are in [slowing] progression of a very small early tumor to one that becomes invasive and larger and develops the ability to metastasize."

"The study provides supportive evidence that lycopene and the carotenoids may have an effect on delaying the progression of prostate cancer, so, from that point of view, it is an interesting study," Scardino added.

But Alan Kristal, associate head of the Cancer Prevention Program at the Fred Hutchinson Cancer Research Center in Seattle, remained more skeptical. Though he called the study "well-executed," Kristal noted, for instance, that the authors were unable to control for prostate-specific antigen (PSA) testing among the men. These blood tests often detect clinically irrelevant tumors, he explained.

"You can never do an observational study of prostate cancer without rigorously controlling for whether or not the person got PSA screening," Kristal said. "The more times you take the test, the more likely you are to get the disease."

He also noted that the finding for lycopene contradicts a report published in May in Cancer Epidemiology Biomarkers and Prevention. That study did account for PSA testing, and it found no effect of lycopene whatsoever on prostate cancer risk -- including the risk of advanced disease.

"To my mind, that study is definitive," said Kristal. "It's a big study, extremely well executed, properly analyzed, and not biased by PSA screening."

A review of lycopene's effect on cancer by the U.S. Food and Drug Administration, published in July in the Journal of the National Cancer Institute, likewise found "no credible evidence to support an association between lycopene intake and a reduced risk of prostate, lung, colorectal, gastric, breast, ovarian, endometrial, or pancreatic cancer and very limited evidence to support an association between tomato consumption and reduced risks of prostate, ovarian, gastric, and pancreatic cancers," according to that study's authors.

So, with tomatoes, ketchup and pizza sauce crossed off the list of prostate-protecting foods, Key and others continue the search. Kristal, for instance, is on the executive committee of a randomized trial examining the effects of selenium and/or vitamin E on prostate cancer risk in 35,000 men. Results are expected in 2012, he said.

Said Key, "I am optimistic we will find something. This paper is an important piece of work, but it doesn't look like this is the answer."

More information
For more on vitamins and cancer, visit the American Cancer Society.

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Tuesday, September 11, 2007

Health Tip: Dealing With Dandruff

(HealthDay News) -- Dandruff, also known as seborrheic dermatitis, occurs when flakes of skin develop on the scalp or inside the ear.

The skin condition, which can run in families, may be triggered by stress, fatigue, oily skin, acne or using hair or skin products that contain alcohol, the U.S. National Library of Medicine says.

Infrequent showering or shampooing may also trigger dandruff.

To treat the condition, over-the-counter dandruff or medicated shampoos should be used daily.

Active ingredients in these shampoos include salicylic acid, coal tar, zinc, resorcin, ketoconazole or selenium.

The hair and other affected areas should be washed for about five minutes before rinsing thoroughly.

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Friday, August 31, 2007

Pediatricians Say Dairy OK for Lactose-Intolerant Kids

New guidelines stress the need for proper calcium intake for bone health
By Ed EdelsonHealthDay Reporter

(HealthDay News) -- The American Academy of Pediatrics has a new attitude about consumption of milk and milk products by children with lactose intolerance: Hey, give it a try.

New guidelines say the academy "supports use of dairy foods as an important source of calcium for bone mineral health and of other nutrients that facilitate growth in children and adolescents." Specifically, it does not recommend eliminating dairy products to treat lactose intolerance.

In practical terms, said Dr. Melvin B. Heyman, a member of the committee that wrote the guidelines, the new advice is for parents of children with lactose intolerance, in collaboration with pediatricians, to "test the system and see how much milk, cheese and ice cream they can tolerate."

One reason for the new advice, said Heyman, who is a professor of pediatrics at the University of California, San Francisco, is that "we have more information about what people will tolerate. We know that children who have lactose intolerance have a tendency to tolerate some dairy products."

At least an equally important factor is the need for the calcium in dairy products, he said. "Young people have to get as much calcium as they can to lower the risk of problems with bones as they get older," Heyman said.

The new guidelines were published in the September issue of the academy's journal, Pediatrics.
An estimated 30 million to 50 million Americans have some degree of intolerance to lactose, the main sugar found in milk and other dairy products. They have a shortage of the enzyme lactase, which breaks down the sugar, and can experience unpleasant symptoms, including nausea, cramps, bloating, gas and diarrhea if they ingest too much lactose.

The condition is relatively rare in whites, but as many as 75 percent of blacks, 90 percent of Asian-Americans and nearly 100 percent of Native Americans suffer from it. Symptoms generally start appearing after the age of 2.

When symptoms do appear, the first step should be to make sure that they are not caused by another condition, such as irritable bowel syndrome, celiac disease, an infection or parasites, Heyman said.

If lactose intolerance is the problem, it's important to remember that the condition does not do bodily damage, however unpleasant the symptoms might be, he said. Careful testing can help determine which products affect an individual and which are a lesser problem. "Some people might tolerate yogurt but have problems with milk," Heyman said.

The important point is that young people get an adequate amount of calcium, he said. The guidelines note that the National Medical Association, an organization of black physicians, "recently recommended that black people consume three to four servings a day of low-fat milk, cheese and/or yogurt."

"If lactose-free diets are used for treatment of lactose intolerance, the diets should include a good source of calcium and/or calcium supplementation to meet daily recommended intake levels," the guidelines state.

More information
Visit the U.S. National Institute of Diabetes and Digestive and Kidney Diseases for more on lactose intolerance.
SOURCES: Melvin B. Heyman, professor, pediatrics, University of California, San Francisco; September 2006 Pediatrics

Thursday, August 23, 2007

Many Older Americans Have Active Sex Lives

(HealthDay News) -- Many older Americans aren't letting age slow down their sex lives, a new study shows.

The first comprehensive national survey of the sexual attitudes, behaviors and problems of U.S. adults age 57 and older finds many are having sex often. In fact, the frequency of sexual activity dropped only slightly between the late 50s up to the early 70s.

And more than half of those in the oldest age group -- 75 to 85 -- who were sexually active reported having sex at least two to three times per month, and 23 percent reported having sex at least once a week.

"This gives us, for the first time, the most comprehensive and nationally representative data on sexuality for men and women and makes a particular contribution with regard to knowledge of older women's sexuality," study lead author Dr. Stacy Tesser Lindau, assistant professor of obstetrics and gynecology and of medicine-geriatrics at the University of Chicago, said at a Monday teleconference.

Lindau is lead researcher on the study, which is published in the Aug. 23 issue of the New England Journal of Medicine.

"This is of extreme importance and a landmark study that hopefully will get the medical community and society focused on this in a less taboo way. It's a great start," said Dr. Barbara Paris, director of geriatrics at Maimonides Medical Center in New York City. "For most people, it's a shock to hear that people are having sex in their 70s," she said.

"This is a premier study," added Marcia G. Ory, professor of social and behavioral health and director of the Aging and Health Promotion Program at Texas A&M Health Science Center School of Rural Public Health. "It debunks some myths that sex and old age don't go together, and it places this in the context of health and health problems."

According to the study authors, little is known about sexuality among older people in the United States, despite this group being the fastest growing segment of the population.

"I'm a gynecologist, and, for me, there was a tremendous void of information to be able to provide people the information they needed to make health care decisions and to be prepared for changes," Lindau said. "With the right information, people might be able to cope better."

For this study, the University of Chicago's National Social Life, Health and Aging Project (NSHAP) researchers interviewed 3,005 U.S. adults (1,550 women and 1,455 men), aged 57 to 85 in their homes.

Three-quarters of those approached agreed to participate and were remarkably forthcoming about their sex lives.

Researchers found that the prevalence of sexual activity did decline with age, with 73 percent of respondents aged 57 to 64 reporting sexual activity, 53 percent among those aged 65 to 74 and 26 percent among those aged 75 to 85.

Women were less likely to be sexually active than men in age groups. More than three-quarters (78 percent) of men aged 75 to 85 had a spouse or other intimate relationship, only 40 percent of women in that age group had a partner.

Women were also more likely to rate sex as "not at all important" (35 percent versus 13 percent of men).

"There do seem some gender disparities," Lindau said. "Men overall are more likely to have partners in later life and are more likely to be sexually active with their partners."

"Older ages really are different for men and women," added Linda Waite, senior author of the paper and the Lucy Flower Professor in Urban Sociology at the University of Chicago. "Men tend to be married until they die, and women tend to spend their final years as widows." In addition, men tend to have younger partners and women older partners, which translates into fewer opportunities for sexual intimacy for women.

About half of both men and women who were sexually active reported sexual problems. The most prevalent among women were low desire (experienced by 43 percent of respondents), vaginal dryness (39 percent) and inability to climax (34 percent). The most common problem reported by men was erectile dysfunction (37 percent).

Fourteen percent of all men reported using medication or supplements to help improve sexual function. "That was a high number," Lindau said.

Health more than age tended to affect people's sex lives; men and women who said their health was poor were less likely to be sexually active.

"The linkage with sexual health is closer to other health issues and is not so tied directly to aging per se," said Edward Laumann, co-author of the study and the George Herbert Mead Distinguished Service Professor in Sociology at the University of Chicago. "Sexual health, when it begins to deteriorate, may be an important warning sign, because it may be an early warning sign of more profound health problems." Lindau was co-director of the 1992 National Health and Social Life Survey which surveyed persons aged 18 to 59.

Despite difficulties, only 38 percent of men and 22 percent of women reported having discussed sexual health with a doctor since the age of 50.

Many people found ways to stay sexually active, even if their overall health was declining. This included oral sex (the prevalence being about 50 percent among those under 75) and masturbation (more than half of men and 25 percent of women said they masturbated, regardless of whether they had a partner).

That being said, vaginal intercourse was often predominant.

"The vast majority said that vaginal intercourse is always part of sexual behavior; that declines slightly as people age, with more cuddling and kissing and snuggling as the primary activity," Waite said.

The researchers also collected physiological specimens such as saliva and vaginal swabs, the results of which will appear in follow-up studies. The samples will provide information on hormone levels, prevalence of chronic diseases such as diabetes and the frequency of human papillomavirus (HPV), which is sexually transmitted.

While this research will pave the way for far more information in the future, for the present, it may help open the doors of communication.

"For physicians, it really gives us a wake up call that you should be asking about sexual function," said Dr. Laurie Jacobs, chief of geriatric medicine at Montefiore Medical Center in New York City.

More information
For more on aging and sex, head to Cornell University.

Kamaraja